AI-based earlier medicine development leveraging TWCC HPC to aid cancer prediction research

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Artificial Intelligence (AI) is shaping the future of global medical industries. The practice of medicine is changing with the development of AI methods of machine learning. As the increasing accuracy of predictive medicine, AI technology, based on analyzing patient's medical records, is entailing predicting the probability of disease in order to either further diagnosis of disease allowing for the estimation of disease risks or significantly decrease the cost to deal with its impact upon the patient. The AI based prediction medicine is a new type of earlier medicine

Hsuan-Chia Yang, assistant professor of the Graduate Institute of Biomedical Informatics, Taipei Medical University, explains Prediction of Principle Health Threat (PROPHET) project. Led by Dr. Li Yu-Chuan, a pioneer of AI in Medicine and Medical Informatics Research, earlier medicine for fatal diseases is leveraging AI technology and data mining systems to provide a personal, real-time, accurate and manageable healthcare program. The PROPHET project provides the prediction of cancer risks and boosts the new business opportunity of start-ups. Taiwan Ministry of Science and Technology provides the funding support for this kind of projects.

Taking breast cancer detection as an example, there are 5 persons confirmed as positive out of every 1000 people screening. Applying the AI earlier medicine perdition method, the effective rate will be reduced to 5 confirmed out of 233 people check. There are 77% saving of breast cancer earlier diagnosis. The saved cost is obvious.

The basic of PROPHET project is making AI Bio-maker model using AI technology to screen cancer and provide the prediction. Transforming the patient medical records to time matrix data diagrams, the skill is setting to predict 10 kinds of cancer risks after one year time frame based on sequential medical records to develop a prediction model. Each prediction of various cancers could reach 85% AUROC (Area under the receiver operating characteristic) curves. Taiwan Healthcare insurance program preserves every citizen's healthcare digital records of treatments and medicine usage. PROPHET takes this strength to analyze three-year personal data records to predict the cancer risks of next 12-month. These lower cost AI-based cancer predictions allow healthcare professions to participate in the decision about whether or not it is appropriate testing or detection priority for patients.

From the technical point of view, the dynamic prediction value of personal diseases is a time-dependent scenario. The time matrix combined with personal medicine usage records and various diseases could make a two dimensional health diagram. The vertical axis is thousands of variables including medicine usage, set of medical signs and symptoms. The horizontal axis is time listings based on week or month. There are about 250 thousand health diagrams to use in the AI training process to get effective prediction AI models. After requiring repeat fine-tuning in training new AI models of each cancer, it can be derived effective prediction models based on above AI Bio-marker.

However, the huge compute power to perform these AI training tasks requires huge support from Taiwan Computing Cloud (TWCC) services. The development team of PROPHET enrolls to join the new startup competition from National Center for High-performance Computing (NCHC) and allows taking approximately equivalent to NT$3 million dollar funds to use TWCC services. The things have been a big help for the project. Through participating the AI Startups campaign event hosted by NCHC, this project gets support to access TWCC platform to perform the AI Training. The entire AI training tasks only 1 hour compared with two-week AI training efforts in old days. It is a great improvement to see the huge time saving and strong compute power support for the project. Especially the useful design of flexible funding allocation and pocket management tools from TWCC services, it is a very helpful way for team members to control resources, and Yang mentioned the thing needs to be highly addressed here.

The AI-based earlier medicine is providing to medical professions and medical doctors not to the patients directly. All the talks and communications will conduct by doctors based on thorough estimation the details of all factors. That's the reason why PROPHET project is focusing the mutual discussion and intense study of doctors and development team members. The next step of PROPHET project is applying the FDA license and in collaboration with public health agencies, hospitals, insurance and other parties. The usage in the field of earlier medicine is deemed appropriate if there is a compelling clinical reason to do so, such as the availability of prevention or treatment as a child that would prevent future disease.

The team members of PROPHET project

The team members of PROPHET project

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